Crayon Shin-chan Gaiden: Alien vs. Shinnosuke takes place 100 years in the future, a significant departure from the main series which is primarily set in modern-day Japan. The story follows the Nohara family as they wake up from cryosleep to find themselves on a space ship drifting aimlessly through space. The anime explores the family's experiences and the events that unfold while they are confined to the ship.