Detective Opera Milky Holmes 2 is the sequel to the first season of the Tantei Opera Milky Holmes series. The story follows Sherlock Shellingford and his sister Nancy, along with their friends Sally and Taka, as they solve more cases in Victorian-era London. The Milky Holmes sisters, along with their brother, Taka, and their friends, continue to use their detective skills to prove the innocence of those wrongly accused.