Rebecca Miyamoto, an 11-year-old teacher, takes charge of a unique classroom consisting of students like Himeko, Ichijou, Rei, and a student who's a white rabbit. Her unorthodox approach often involves sarcasm and humor, sometimes bordering on offensiveness. With the help of her students, Rebecca tries to shake up the school and its environment, which sometimes puts her at odds with the neighboring school's teacher, Ichijou's "ojii-chan.