The anime takes place in a post-apocalyptic world, specifically in the center of Tokyo, where the last remnants of humanity, all women, struggle to survive in a harsh environment. By 2010, a catastrophic event had wiped out all men, leaving the women to fend for themselves and rebuild society. Two factions have emerged, one that accepts their fate and lives freely, while the other seeks to use science to preserve the human species. This divide leads to conflict, particularly over the discovery of a specimen called "ICE," which may hold the key to reviving humanity.