Kusanagi, the former leader of Public Security Section 9, now heads the mercenary group GHOST. As artificial intelligence continues to advance in 2045, governments have come to rely on AI as a means to sustain their economies through constant warfare. This landscape is familiar to GHOST, which has been involved in various proxy wars worldwide. However, a new threat emerges in the form of cybernetically enhanced individuals, known as "post-humans," with extraordinary intelligence and abilities.